Work

Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review

Year: 2026

Type: review

Abstract: Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in H. pylori-associated malignancies. This review summarizes the role of mitochondrial stress in H. pylori infection, gastric cancer, and MALT lymphoma.

Source: Antioxidants

DOI: 10.3390/antiox15030285

Authors: Viola Varga, András Gelley, Éva Margittai, Buket Bagci, Edina Wappler, Ibolya Czegle

Institutions: Semmelweis University, University of Rochester Medicine, Boston University

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499