Work

The time course of fluid responsiveness

Year: 2026

Type: article

Abstract: Fluid responsiveness (FR) is a cornerstone concept in the hemodynamic management of critically ill patients, referring to the heart's ability to increase output in response to fluid administration. This review explores the time course of FR, emphasizing its dynamic and transient nature influenced by various patient-specific factors and treatments. We highlight that FR is not a stable, binary state but rather a continuum that requires repeated evaluations using appropriate tools. We examine into factors affecting the temporal profile of FR, including the stage of resuscitation, fluid infusion rate, norepinephrine use, mechanical ventilation settings, systolic function, spontaneous breathing, and the patient's health condition. Understanding the duration and decay of the hemodynamic response is crucial for individualizing fluid therapy, potentially reducing the risks of both fluid overload and under-resuscitation. This review underscores the necessity of frequent reassessment of FR in critically ill patients and integrating this knowledge into personalized resuscitation protocols to improve clinical outcomes.

Source: Annals of Intensive Care

DOI: 10.1016/j.aicoj.2026.100036

Authors: Ricardo Castro, Eduardo Kattan, Paulo Melo, Macarena Amthauer, Glenn Hernandez

Institutions: Pontificia Universidad Católica de Chile, Hospital Santiago Oriente - Dr. Luis Tisne Brousse

Language: English

Topic: Hemodynamic Monitoring and Therapy

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,490