Work

Gut microbiome disparities reflect type 2 diabetes progression and medication status

Year: 2026

Type: article

Study design: Observational Study

Abstract: abundance increased with disease progression, while Clostridium_sensu_stricto_1 was associated with glucose homeostasis and insulin sensitivity. β diversity differed only between controls and PD, with no other pairwise differences. Collectively, these results indicate that T2D progression and oral antidiabetic medications remodel the gut microbiome in this south Asian cohort and highlight the need to reassess antidiabetic treatment efficacy using larger longitudinal studies.

Source: iScience

DOI: 10.1016/j.isci.2026.115156

Authors: Manoj Kumar, Samradhi Singh, Raj Ojha, Mona Kriti, Gwoncheol Park, Vinod Verma, Namrata Pal, Poonam Sharma, Swasti Shubham, Megha K. Pandey, Devraj J. Parasannanavar, Devojit K. Sarma, Rajnarayan R. Tiwari, Ravinder Nagpal

Institutions: Indian Council of Medical Research, ICMR National Institute for Research in Environmental Health, Florida State University, Sanjay Gandhi Post Graduate Institute of Medical Sciences, All India Institute of Medical Sciences Bhopal, National Institute of Nutrition

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funder: Indian Council of Medical Research

Award: G695198936

OpenAlex ID: W7131712759

FWCI: 3.877

Cites: 40

Cited by: 2

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