Work

Exploring LEPR -Linked Metabolic Diversity through Gut Microbiome-Metabolome Network Analysis in Non-Obese Adults

Year: 2026

Type: article

Abstract: genetic variation is associated with distinct serum metabolomic patterns and microbiome-host networks in healthy adults. Although no direct leptin signaling links were found, network-level associations suggest indirect genetic influences on metabolic states through microbiome-metabolome interactions. These findings advance understanding of personalized metabolic regulation and gene-microbiome interplay.

Source: Biomolecules & Therapeutics

DOI: 10.4062/biomolther.2025.161

Authors: Kyeong-Seog Kim, Joo-Youn Cho, Ye Chan Park, Jang Hee Hong, Jin-Gyu Jung, Jung Sunwoo

Institutions: Seoul National University, University of Liverpool, Chungnam National University, Chungnam National University Hospital

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Ministry of Health and Welfare, Korea Health Industry Development Institute