Work

Efficacy and safety of robot-assisted vs. stereotactic framework deep brain stimulation for Parkinson’s disease: a retrospective study

Year: 2026

Type: article

Abstract: Background This retrospective study aimed to compare the efficacy and safety of robot-assisted deep brain stimulation (DBS) vs. stereotactic framework DBS for Parkinson’s disease (PD). Methods The present study constituted a retrospective analysis that integrated a review of medical records with an outcomes management database from the First Affiliated Hospital of Guangxi University of Science and Technology. A total of 32 patients experienced robot-assisted DBS with the Sinovation surgical robot system, while an additional 30 patients underwent stereotactic frame DBS. The primary objective was the accuracy of electrode implantation, whereas the secondary objectives were postoperative UPDRS-III scores, levodopa equivalent dose (LEDD), and complications. Results No substantial difference was observed between the two groups concerning sex, age, disease duration, Hoehn-Yahr score, preoperative UPDRS-III scores, and preoperative LEDD. In comparison to stereotactic framework DBS, robot-assisted DBS demonstrated a markedly reduced average targeting error (1.43 ± 0.51 mm vs. 1.91 ± 1.38 mm, p = 0.034). Moreover, robot-assisted DBS demonstrated a markedly greater reduction in UPDRS-III scores and a decrease in LEDD at 3, 6, and 12 months postoperatively. No fatalities or lasting complications due to surgery were detected in either group during the study period. Conclusion In comparison to stereotactic framework DBS, robot-assisted DBS demonstrated notable benefits in electrode implantation precision, UPDRS-III scores, and LEDD. Robot-assisted deep brain stimulation with the Sinovation surgical robot system was recommended for the management of Parkinson’s disease.

Source: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2026.1699583