Demography, Clinical Characteristics and Long-Term Outcomes of Central Serous Chorioretinopathy in Women. MICRoN Report Number Fourteen
Year: 2026
Type: article
Study design: Observational Study
Abstract: PURPOSE: To evaluate the characteristics and longitudinal outcomes of chronic central serous chorioretinopathy (CSCR) in women compared to an age-matched cohort of men with CSCR. DESIGN: Retrospective, multicenter clinical cohort study from the Macula Society CSCR Study Group. PARTICIPANTS: This study included 426 eyes (213 women and 213 age-matched men) with a diagnosis of CSCR. METHODS: Baseline and final best-recorded visual acuity (BRVA) and multimodal imaging parameters such as area of retinal pigment epithelium (RPE) alterations, choroidal macular thickness (CMT), sub-foveal choroidal thickness (SFCT), subretinal fluid (SRF), pigment epithelium detachment (PED), double layer sign (DLS), hyperreflective dots (HRD), as well as the presence of choroidal neovascularization (CNV) and subretinal hyperreflective material (SHRM) were assessed. Regression analysis was used to evaluate baseline predictors of final visual acuity. MAIN OUTCOME MEASURES: Longitudinal changes in BRVA and imaging parameters in men and women stratified for age; factors affecting subretinal fluid (SRF) persistence, and change in BRVA. RESULTS: A total of 426 eyes (213 women and 213 age-matched men) with CSCR were analyzed. Women showed better BRVA at presentation (0.25 ± 0.24 vs 0.31 ± 0.35 logMAR; P = .05), and exhibited smaller areas of RPE alterations (2.37 ± 2.64 vs 1.59 ± 1.55 disc areas; P = .003), less frequent peripapillary RPE changes (13.6% vs 7.5%; P < .001), shorter DLS (1353.9 ± 970.2 vs 1071.6 ± 888.7 µm; P = .039), and smaller PEDs (644.9 ± 546.4 vs 442.1 ± 278.9 µm; P = .022). During follow-up, women exhibited higher rates of complete SRF resolution (P = .001) while persistence and the number of recurrences were significantly more common in men (P = .006 and P = .02, respectively). Logistic regression analysis revealed that persistent SRF was independently associated with complex CSCR, male gender, baseline PROS irregularities, worse BRVA, SHRM, and CNV, while PDT was protective. CONCLUSION: Women had better visual outcomes and more favorable structural evolution while men tended to present with more complex anatomical alterations and experience higher rates of persistent SRF.
Authors: Giulia Gregori, Niroj Kumar Sahoo, Nasiq Hasan, Arman Zarnegar, Marco Lupidi, Micheal Zhang, Lihteh Wu, Jessica Cao, Gabriele Piccoli, Stela Vujosevic, Priya Shah, Panisa Singhanetr, Elizabeth Rossin, Lisa Checchin, Lorenzo Pili, Maurizio Battaglia Parodi, Min Kim, Lorenzo Ferro Desideri, Marion R. Munk, Peranut Chotcomwongse, Paisan Ruamviboonsuk, Adrian Fung, Kent Small, Samer Khateb, Jay C. Wang, Rahul N Khurana, Carol Villafeurte, Glenn Yiu, Bita Momenaei, Sunir Garg, Timothy Lai, Yusuf Ashfaq, Zachary Kroeger, Jay Chhablani, Jay Chhablani, Nasiq Hasan, Arman Zarnegar, Carmen Antia, Yusuf Ashfaq, Luis Aria Barquet, Elodie Bousquet, Jessica Cao, Lisa Checchin, Peranut Chotcomwongse, Andrea Corletti, Lorenzo Ferro Desideri, Adrain T. Fung, Priyank Gandhi, Sunir Garg, Manjot Gill, Giulia Gregori, Felicia Hertkorn, Naoya Imanaga, Ninan Jacob, Samer Khateb, Rahul N Khurana, Min Kim, Hideki Koizumi, Zachary Kroeger, Timothy Lai, Luiz H. Lima, Marco Lupidi, Bita Momenaei, Marion R. Munk, Roselind Ni, Maurizio Battaglia Parodi, Gabriele Piccoli, Lorenzo Pili, Francisco Rodriguez, Elizabeth Rossin, Paisan Ruamviboonsuk, Niroj Kumar Sahoo, Stanley Saju, Priya Shah, Rufino Silva, Panisa Singhanetr, Kent Small, Lucia Sobrin, Carol Villafeurte, Stela Vujosevic, Jay Wang, Halit Winter, Lihteh Wu, Charles C. Wykoff, Glenn Yiu, Arman Zarnegar, Micheal Zhang, Jay Chhablani, Jay Chhablani
Institutions: Marche Polytechnic University, University of Pittsburgh, UPMC Health System, University of Pittsburgh Medical Center, Canberra Hospital, Retina Consultants of Texas, MultiMedica, University of Milan, Massachusetts Eye and Ear Infirmary, Harvard University, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Gangnam Severance Hospital, Northwestern University, University of Bern, University Hospital of Bern, Rajavithi Hospital, Macquarie University, Macula and Retina Institute, Hebrew University of Jerusalem, Hadassah Medical Center, University of California, Davis, Mid Atlantic Retina, Wills Eye Hospital, Chinese University of Hong Kong, Hong Kong Eye Hospital, Oregon Health & Science University
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W7131811535