Work

Valve endothelial monolayer fissuring and interstitial matrix fracture triggers calcific lesion formation via GTPase signaling

Year: 2026

Type: article

Source: Acta Biomaterialia

DOI: 10.1016/j.actbio.2026.02.050

Authors: Katherine Driscoll, Santosh Balakrishnan, G Janani, Hrishika Gogineni, Alessandra Good, Andrea Huang, Nichaluk Leartprapun, Steven G Adie, Jonathan Butcher

Institution: Cornell University

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Adhesive signaling in aortic valve development and disease, Investigating the role of CaV1.2 in aortic valve stenosis, Endothelial-Interstitial Interactions in Aortic Valve Homeostasis and Disease, Mechanobiology of Cardiac Outflow Tract Morphogenesis

OpenAlex ID: W7131884248

FWCI: 4.971

Cites: 66

Cited by: 1

Related to: 10