Work

Novel dipotassium oxalate-containing mouth rinses for the prevention of erosive tooth wear

Year: 2026

Type: article

Abstract: OBJECTIVES: to formulate experimental solutions, simulating mouthrinses, containing 1.4% dipotassium oxalate (OXP) alone, with 225 ppm F⁻ (from NaF), or with 225 ppm F⁻ and 800 ppm Sn²⁺ (from SnCl₂), and to assess their anti-erosive effect on enamel and dentin. METHODS: bovine enamel and dentin specimens were randomly distributed into 6 groups (n = 10/substrate): 1. Distilled water (DIW); 2. F; 3. F+Sn; 4. OXP; 5. OXP+F; 6. OXP+F+Sn. The specimens were submitted to a 5-day erosive-abrasive cycling with 1% citric acid (2 min, pH ∼ 2,4), followed by 60 min artificial saliva (4x/day), brushing with a standard fluoride toothpaste (2x/day) and 1 min immersion in test solutions after each brushing episode. Surface loss (SL, in µm) was measured with an optical profilometer. Additional analyses included the determination of potentially available fluoride in the solutions and scanning electron microscopy of the specimen surfaces. Data were statistically analyzed (α=0.05). RESULTS: OXP+F+Sn showed the lowest SL in enamel and dentin (3.10 ± 1.12 and 3.27 ± 1.27, respectively), differing from F+Sn in dentin (6.24 ± 0.53; p < 0.05). In enamel, F+Sn and OXP+F+Sn significantly reduced SL compared with DIW (10.31 ± 0.99; p < 0.05). OXP only showed lower SL for dentin compared with DIW (3.71 ± 1.16; p < 0.05). Fluoride availability matched the added concentration, with slight reduction in OXP groups. Calcium oxalate crystals were observed in OXP groups micrographs. CONCLUSION: OXP reduced enamel and dentin surface loss, with a more pronounced effect in dentin, suggesting its potential as protective agent against erosive tooth wear. CLINICAL SIGNIFICANCE: Dipotassium oxalate is commonly used as an agent to mitigate dentin hypersensitivity. Our results showed that it can also reduce the progression of erosive tooth wear in dentin, highlighting its potential as a suitable additive in oral care products targeting these conditions, which are often associated.

Source: Journal of Dentistry

DOI: 10.1016/j.jdent.2026.106593