Vietinio simvastatino poveikis kaulų regeneracijai po danties ištraukimo: literatūros apžvalga
Year: 2025
Type: dissertation
Study design: Systematic Review
Abstract: Relevance and aim: The purpose of this review was to evaluate the effects of local simvastatin on alveolar bone regeneration after tooth extraction, with a minimum follow-up of two months. Materials and methods: In January 2025, the search for this literature review across PubMed (MEDLINE) databases was performed to identify studies published between January 2015 and January 2025 containing a minimum of 20 sockets per study to evaluate the effect of local statin in promoting bone regeneration after tooth extraction. Quality and risk-of-bias assessment were evaluated by JBI risk of bias tool. Results: A total of 628 articles were screened, with 6 articles meeting the inclusion criteria and being utilized for this review. A total of 326 sockets with different types were evaluated, the effect of local simvastatin on regenerated bone morphology, with findings demonstrating progressive improvements. Furthermore, pain and swelling assessments revealed a decrease in the test groups compared to the control groups suggesting that local simvastatin may promote bone regeneration while reducing post-treatment discomfort. Conclusions: Local simvastatin application promotes bone regeneration without increasing pain or swelling, supporting its use as a safe and effective supplement in regenerative bone treatment after tooth extraction. Keywords: "Bone regeneration", "Extraction socket", "Statin", "Simvastatin".
Author: Aminov, Ariel
Institution: Lithuanian University of Health Sciences
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7131940929