Dynamic changes in TSH levels in women with autoimmune thyroid diseases undergoing controlled ovarian hyperstimulation
Year: 2016
Type: article
Study design: Observational Study
Abstract: Introduction For more than 50 years it has been well known that normal thyroid function is required for normal reproduction. On the other hand an increasing amount of data have shown the impact of assisted reproductive technologies (ART) on the normal function of the thyroid gland, especially in cases of pre-existing thyroid disease including autoimmune thyroid disease (AITD). Aim: To evaluate the dynamic changes in TSH levels before and during a controlled ovarian hyperstimulation (COH). Design: A prospective, observational research study in a selected group of 45 women, suffering from infertility, undergoing COH for in vitro fertilization (IVF) was performed. The changes in the TSH levels were assessed during the COH procedure in two groups of women: the first group without pre-existing AITD (n1=24), and the second group with pre-existing AITD (n2=21). The targets of the TSH levels before starting COH were less than 2,5 mIU/ml in both groups. Women with pre-existing AITD were treated with levothyroxin before and during COH. Results: Significant increases in TSH levels during the COH procedure were observed in both groups with a predominate rise in the women without AITD. Conclusion: Ovarian hyperstimulation has a direct impact on TSH levels, necessitating pre-starting TSH assessment for all patients undergoing COH.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7132131258