Risk of Parkinson's disease dementia related to level I MDS PD‐MCI
Year: 2019
Type: article
Abstract: BACKGROUND: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. METHODS: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. RESULTS: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. CONCLUSIONS: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.
Source: Movement Disorders
DOI: 10.1002/mds.27617
Authors: Jeroen Hoogland, Judith A. Boel, Rob M.A. de Bie, Ben A. Schmand, Ronald B. Geskus, John C. Dalrymple‐Alford, Connie Marras, Charles H. Adler, Daniel Weintraub, Carmen Junque, Kenn F. Pedersen, Brit Mollenhauer, Jennifer G. Goldman, Alexander I. Tröster, David J. Burn, Irene Litvan, Gert J. Geurtsen, on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”
Institutions: Amsterdam University Medical Centers, University of Amsterdam, Amsterdam UMC Location University of Amsterdam, University of Oxford, Oxford University Clinical Research Unit, New Zealand Brain Research Institute, Brain Research New Zealand, University of Toronto, Toronto Western Hospital, Mayo Clinic in Arizona, Banner Sun Health Research Institute, Philadelphia VA Medical Center, University of Pennsylvania, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Stavanger University Hospital, Universitätsmedizin Göttingen, Paracelsus Elena Klinik Kassel, Rush University Medical Center, Barrow Neurological Institute, Newcastle University, University of California San Diego
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Michael J. Fox Foundation for Parkinson's Research, Parkinson's Disease Foundation, Canterbury Medical Research Foundation, Neurological Foundation of New Zealand, Brain Research New Zealand, Arizona Biomedical Research Commission, National Institutes of Health, Canadian Institutes of Health Research, Health Research Council of New Zealand, National Institute of Neurological Disorders and Stroke
OpenAlex ID: W2909018671