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PREPARATION OF GOLD LOADED MICELLES BASED ON POLY (ETHYLENE GLYCOL) - b - POLY (4-VINYL PYRIDINE) COPOLYMERS AS A TOOL FOR BIOMEDICAL APPLICATIONS

Year: 2016

Type: article

Abstract: Well-defined block copolymers based on poly (ethylene glycol) monomethyl ether and poly (4-vinyl pyridine) (PEG-b-P4VP) were prepared by atom transfer radical polymerization (ATRP). PEG-b-P4VP block copolymer self assembled in an aqueous medium with formation of nanosized spherical micelles was thus prepared. Gold nanoparticles were successfully loaded into PEG-b-P4VP based micelles. This was confirmed by UV-vis, TEM and DLS analysis. The cytotoxicity of gold loaded micelles against MDA-MB-231 breast cancer cells and L929 fibroblasts was determined.

Source: Bulgarian Portal for Open Science

Authors: Vircheva S., Bryaskova R., Miloshev S., Tzoneva R., Dishovsky N.

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7132717847

FWCI:

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