Investigating the Effect of scyllo-Inositol Treatment on the Brain in a Mouse Model of Alzheimer's Disease
Year: 2016
Type: dissertation
Abstract: scyllo-Inositol is a potential therapeutic for the treatment of agitation and aggression in patients with Alzheimer's disease. scyllo-Inositol reduces aggregation of beta-amyloid peptide, reduces amyloid plaques, and reduces myo-inositol concentration in the brain. The change in gene expression in the brain of TgCRND8 mice after scyllo-inositol treatment has not been previously investigated. I hypothesized that scyllo-inositol treatment would cause changes in expression of genes involved in neurodegenerative diseases and neuropsychiatric disorders. Affymetrix gene expression microarrays were used to analyze changes in the hippocampus and cerebral cortex of TgCRND8 mice as well as in non-transgenic littermates after 30 days of scyllo-inositol treatment. Analysis of the data with the Database for Annotation, Visualization and Integrated Discovery and Ingenuity Pathways Analysis program showed gene expression changes in synaptic function, calcium, dopamine receptor, glutamate receptor, and myo-inositol signalling pathways. In light of these results, I concluded that my hypothesis was correct.
Source: TSpace (University of Toronto)
Author: Hu, Qingda
Institution: University of Toronto
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7132873620