Year: 2024
Type: dissertation
Abstract: Objective: To evaluate the differences in cognitive flexibility between individuals with OCD and healthy controls (HC) and the potential genetic markers involved. Methods: A small independent sample of participants with OCD and HCs (N=20, N=20) and a meta-analysis (N=562 OCD, N=541 HC) were conducted to evaluate differences on the CANTAB intra-extra dimensional set-shifting test (IED). Genotyping was conducted for the small independent sample, a case-control analysis, as well as an analysis of variance was conducted (ANOVA), to assess the association between genotype and CANTAB IED score. Results: There was a significant difference for extra-dimensional set-shifting errors with individuals with OCD performing worse in both the small independent sample (p=0.004) and meta-analysis (p=0.0001). The genetic analysis did not yield any significant results. Conclusion: Individuals with OCD in our sample exhibit reduced cognitive flexibility as compared to HCs based on the CANTAB IED performance. There is a need for future genetic analysis with larger sample sizes.
Source: TSpace (University of Toronto)
Author: Baer, Jenna
Institution: University of Toronto
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W7132886529