Year: 2006
Type: dissertation
Abstract: The intestinal glucagon-like peptides, GLP-1 and GLP-2 inhibit intestinal motility, while GLP-2 also stimulates growth of the intestinal mucosa. However, the mechanisms of action of these peptides remain poorly characterized. To determine the role of the enteric nervous system in the actions of the GLPs, the glial cell line-derived neurotrophic factor family receptor alpha 2 (GFRalpha2) knockout mouse was employed. These mice exhibit reduced parasympathetic innervation and decreased numbers of cholinergic and substance P-ergic excitatory motor neurons in the myenteric plexus. No differences were observed in basal or GLP-2-stimulated mucosal growth between wildtype and knockout mice. However, knockout mice exhibited reduced basal gastrointestinal transit. Furthermore, acute administration of GLP-1 and GLP-2 significantly inhibited transit in wildtype mice (P
Source: TSpace (University of Toronto)
Author: McDonagh, Sean Christian
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7132890738