Year: 2024
Type: dissertation
Study design: Observational Study
Abstract: Pulmonary Hypertension (PH) is a progressive vascular condition characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, eventually resulting in right ventricular heart failure. Identification of modifiable risk factors such as frailty, a biological syndrome of decreased physiological reserve, may improve prognostication and management as shown in other chronic lung conditions. However, frailty in PH has not been previously evaluated. The overarching aim of this thesis was to compare key clinical and muscle health outcomes between frail and non-frail PH patients. A combination of patient-reported outcomes measures and functional assessments were used. We found that frailty was negatively associated physical component of health-related quality of life, highlighting that frailty may be able to capture important daily functional limitations outside of PH disease severity.
Source: TSpace (University of Toronto)
Author: Momen, Rozhan
Institution: University of Toronto
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7132910830