Year: 2008
Type: dissertation
Study design: Observational Study
Abstract: Genetic variability in the enzymes that break down caffeine, or in the receptors primarily involved in the mechanism of action of caffeine, may explain some of the inter-individual variability in caffeine consumption behaviour. The purpose of this thesis was to investigate the role genetic polymorphisms of the enzyme responsible for the metabolism (CYPIA2 -163A>C), and the targets of caffeine action (ADORA2A 1976T>C and DRD2 957C>T) play in likelihood of reporting the acute effects and withdrawal symptoms of caffeine. Subjects with the T/T genotype of the 957C>T polymorphism are more likely to report the anxiogenic effects of caffeine at all habitual intake levels and the arousal effects of caffeine at habitual intake levels> 200 mg/d. The polymorphisms were not associated with caffeine withdrawal symptoms. Our findings suggest that habitual intake levels and the DRD2 gene play an important role in mediating the mood and behaviour altering properties of caffeine consumption.
Source: TSpace (University of Toronto)
Author: Ozsungur, Stephen Vahric
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7132929155