Diabetes, Perivascular Spaces, and Cerebral Small Vessel Disease in Cerebrovascular Disease and Across the Neurodegenerations
Year: 2022
Type: dissertation
Study design: Observational Study
Abstract: Type 2 diabetes mellitus (T2DM) and hypertension are established risk factors for cerebral small vessel disease (SVD); however, few studies have characterised their relationships with MRI-visible perivascular spaces (PVS). Patients with neurodegenerative diseases were stratified by presence or absence of T2DM, and MRI was used to quantify deep (d) and periventricular (p) white matter hyperintensities (WMH) and lacunes (LACN), and PVS in the white matter (wmPVS) or basal ganglia (bgPVS). Patients with T2DM had greater wmPVS volume, but not other SVD volumes, with greater wmPVS volumes in patients with T2DM and hypertension together. Counterfactual moderated mediation models found total natural indirect effects of T2DM on all other SVD volumes that were mediated by wmPVS: pWMH, dWMH, pLACN, and dLACN, in patients with hypertension, but not in patients without hypertension. Studying the regulation of cortical perivascular fluid dynamics may reveal targets to mitigate the impact of T2DM on cerebral small vessels.
Source: TSpace (University of Toronto)
Author: Zebarth, Julia
Institution: University of Toronto
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7133006599