Year: 2023
Type: dissertation
Abstract: Traumatic Brain Injury (TBI) can result in secondary brain injury from ischemia, which can cause tissue and organ damage. Remote ischemic conditioning (RIC) is a non-invasive intervention that has shown potential in reducing ischemia/reperfusion injury. In this study, we investigated whether RIC could be beneficial in TBI patients by modulating levels of brain injury biomarkers (ClinicalTrials.gov Identifier NCT03176823). We also tested whether plasma from mice that underwent RIC could be neuroprotective in a zebrafish larvae neurotoxicity model. While the zebrafish larvae assays did not yield positive results, preliminary findings from a randomized double-blinded controlled clinical trial in TBI ICU patients indicate that RIC may limit post-injury elevations in S100B, irisin, and lactate levels. These results suggest that RIC could potentially serve as a novel adjunctive therapy for moderate to severe TBI, and completed results from the ongoing trial will provide further insight into its mechanisms and outcomes.
Source: TSpace (University of Toronto)
Author: Khan, Zahra
Institution: University of Toronto
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7133107840