Work

Activation of 5-HT1A autoreceptors causes actin depolymerization in Drosophila serotonergic neurons.

Year: 2026

Type: article

Abstract: , though the cellular mechanisms are unknown. Here we show that pharmacological activation of 5-HT1A leads to increases in G/F-actin ratios, suggesting 5-HT1A negatively regulates serotonergic axon outgrowth through actin depolymerization.

Source: PubMed

DOI: 10.17912/micropub.biology.002024

Authors: Ava Kinser, Jessie K. Rhodes, Douglas H. Roossien

Language: English

Topic: Axon Guidance and Neuronal Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Science Foundation

Award: BRC-BIO: The role of serotonin signaling in autoregulation of axon morphology, connectivity, and behavior in Drosophila

OpenAlex ID: W7133126951

FWCI:

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