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OCTOPOS.jl – A user-friendly tool for synonymous genetic code optimization

Year: 2024

Type: article

Abstract: The genetic code of organisms connects which codons will be translated to which aminoacid. There are multiple codons which encode the same aminoacid, but they have differing translation dynamics. This can be used to alter the translation dynamic of a mRNA without changing the resulting protein. OCTOPOS.jl is a Julia package for optimizing mRNA sequences by synonomous exchange of codons. This can be used for example to increase protein yield in different host organisms.A web interface is available at https://octopos.cell.uni-hannover.de.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18834589

Authors: Christ, Simon, Trösemeier, Jan-Hendrik, Kamp, Christel, Rudorf, Sophia

Institutions: Leibniz University Hannover, Deutsche Bahn (Germany), Paul Ehrlich Institut

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7133195863

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