Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C
Year: 2026
Type: article
Source: Journal of Medicinal Chemistry
Authors: Matthew L. Landry, Sushant Malhotra, Maureen Beresini, Connie Chan, Emily Chan, Cecile C. de la Cruz, Nicholas F. Endres, Marie Evangelista, Amy Gustafson, Dennis Hu, Thomas Hunsaker, Peter Hsu, Yevgeniy Izrayelit, Hank La, Pablo Saenz-Lopez Larrocha, Qihui Lian, Mark Merchant, Jialin Mao, Rana Mroue, Angela Oh, Emile Plise, Cheng Shao, Michael Siu, John C. Tran, Yanguang Wang, Weiru Wang, Binqing Wei, Susan Wong, Chun-Wan Yen, Yuhui Zhou, Hans E. Purkey, Timothy P. Heffron, Laurent Salphati
Institutions: Genentech, WuXi AppTec (China), Pharmaron (China)
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: closed
Funder: Genentech
OpenAlex ID: W7133241897