Year: 2026
Type: editorial
Abstract: Black Americans have increased risk of chronic kidney disease (CKD) compared to individuals without African ancestry. Variants designated G1 and G2 in the apolipoprotein L1 protein encoded by the APOL1 gene are a major contributor to this increased risk.1 These variants arose independently, rarely occur together on the same chromosome, and exist almost exclusively in individuals with recent African ancestry. The percentage of individuals with one risk variant is 33-37% (G1/G0 or G2/G0), while 13-15% possess two variants (high-risk genotype: G1/G1, G2/G2, or G1/G2).
Source: Kidney International Reports
Institution: Arkana Laboratories
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W7133331053