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Insufficient erythrocyte-derived S1P: A pathogenic driver and diagnostic biolipid for tumor progression

Year: 2026

Type: article

Abstract: and S1P release, impaired angiogenesis, and promoted an immunosuppressive tumor microenvironment, thereby accelerating tumor growth. These findings establish erythrocytes as active metabolic regulators of tumor progression via SPHK1/S1P signaling.

Source: iScience

DOI: 10.1016/j.isci.2026.115216

Authors: Zhenjiang Li, Weilun Huang, Zhouzhou Yao, Juncheng Wang, Wenhao Xiao, Qi Guo, Changhan Chen, Tingting Xie, Zhiyu Yang, Qingyang Liu, Rodney E. Kellems, Mengzhi Wu, Yang Xia

Institutions: Central South University, Xiangya Hospital Central South University, Hunan Cancer Hospital

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Hunan Province, Xiangya Hospital, Central South University

Awards: G1069546893, G1824132130, G21730667, G2871627466, G4743212421, G4870715425, G4906247661, G6970962445

OpenAlex ID: W7133532964

FWCI:

Cites: 62

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