Work

Generation of a human induced pluripotent stem cell line NTUHi007-A from a patient with Parkinson’s disease harboring a heterozygous missense mutation c.1858 G > A (p.D620N) in VPS35 gene

Year: 2026

Type: article

Abstract: Vacuolar protein sorting 35 (VPS35) is a rare autosomal dominant cause of Parkinson's disease (PD), typically presenting with levodopa-responsive motor symptoms similar to idiopathic PD. Using a Sendai virus-based system, we generated an induced pluripotent stem cell line from peripheral blood mononuclear cells of a 48-year-old woman carrying a heterozygous VPS35 c.1858G > A (p.D620N) mutation. This cellular model provides a valuable tool for investigating pathogenic mechanisms and facilitating the development of potential PD therapies.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.103955

Authors: Ying-Fa Chen, Chih-Hsin Ou-Yang, Chin-Hsien Lin

Institutions: Kaohsiung Chang Gung Memorial Hospital, National Taiwan University Hospital, National Taiwan University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360