Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study
Year: 2026
Type: article
Abstract: Understanding the neural mechanisms underlying upper limb motor recovery after stroke remains a significant challenge in rehabilitation research. It has been proposed that individuals who show no motor-evoked potential (MEP) response to transcranial magnetic stimulation (TMS) and are thus classified as MEP negative (MEP-) have limited potential for recovery in part due to damage of the corticospinal pathway. In this study, we investigate how individuals categorized as MEP- with TMS respond to stimulation of the corticospinal pathway at a subcortical level. We describe the methodology for eliciting MEPs by using cervicomedullary electrical stimulation (CMEP) in post-stroke individuals with severe upper limb hemiparesis. MEP status (+/-) of the more affected arm was assessed using TMS and cervicomedullary electrical stimulation in stroke survivors with severe upper extremity hemiparesis. While most of the participants were classified as MEP-, all individuals were categorized as CMEP+ in the biceps brachii, extensor carpi radialis, and first dorsal interosseous muscles. Importantly, we report the first testing of CMEPs in a small cohort of individuals with stroke. This technique is feasible in this population and has potential for application in clinical translation settings. Our findings provide a foundation for future studies to replicate and expand upon this approach, enabling the exploration of new hypotheses related to post-stroke rehabilitation and recovery.
Source: Frontiers in Neurology
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: National Institutes of Health
Award: G9000001365
OpenAlex ID: W7133553344