Work

Molecular Targets for Cancer Immunotherapy: Focusing on (Immune and Tumor) Cell-Derived Metabolites

Year: 2026

Type: article

Abstract: Tumor cells from different organs possess distinct metabolic requirements and develop in specific microenvironments. In this context, metabolites from the tumor microenvironment may impact the biology of tumors. Carbohydrates, lipids, and other metabolic intermediates exhibit important (and often contradictory) functions in the tumor microenvironment. Here, several metabolites are discussed according to their role in both tumor and immune cell biology and how they can promote tumor growth or regression in distinct circumstances. In this context, numerous studies have highlighted that the combination of immunotherapies, including modulators of metabolic processes, emerges as a promising therapeutic strategy for treating distinct tumors. This combination might be especially important to impair the emergence of resistant clones of tumor cells and will be discussed in this review.

Source: Applied Sciences

DOI: 10.3390/app16052461

Authors: Rafaella Delatorre Tavares Quintans, Ângelo Azevedo de Freitas, Maynah Melo de Souza, Geovane Dias-Lopes, Rafael Cardoso Maciel Costa Silva

Institution: Universidade do Estado do Rio de Janeiro

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896