Work

Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors

Year: 2026

Type: article

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.adw9286

Authors: Torahito A. Gao, Ryan M. Shih, Justin D. Clubb, Shao-Hsi Hung, Tanya Singh, Laura B. James-Allan, Gabriella DiBernardo, Amanda Shafer, Amber Bouren, Melanie Ayala Ceja, Sophie Ong, Andréa B. Ball, Ajit S. Divakaruni, Sanaz Memarzadeh, Han-Chung Wu, Yvonne Y. Chen

Institutions: University of California, Los Angeles, Institute of Cellular and Organismic Biology, Academia Sinica, Academia Sinica, Broad Center, VA Greater Los Angeles Healthcare System, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Science Foundation, U.S. Department of Veterans Affairs, Cancer Research Institute, National Institutes of Health, University of California, Los Angeles, National Institute of General Medical Sciences

Awards: G2286081895, G2842458231, G2923451624, UCLA-Caltech Medical Scientist Training Program, G9000014295

OpenAlex ID: W7133564913

FWCI: 7.897

Cites: 74

Cited by: 3

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