Work

Gastrointestinal pH Gradient-Induced Phase Transition of Crizotinib: The Significance of pH-Dependent Ionization (Protonation) on Liquid–Liquid Phase Separation of a Weakly Basic Drug

Year: 2026

Type: article

Source: Molecular Pharmaceutics

DOI: 10.1021/acs.molpharmaceut.5c01345

Authors: Ziqiao Chen, Sha Chen, Haiyan Lv, Ruilin Chao, Yifan Jiang, Shuting Li, Ao Li, Binbin Liu, Yingwei Hu, Yanjia Yang, Luping Cui, Ming Lu

Institution: Sun Yat-sen University

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Young Teacher Foundation of Sun Yat-sen University, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1774879069, G7441638317, G7692646439

OpenAlex ID: W7133606887

FWCI:

Cites: 61

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