The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications
Year: 2026
Type: article
Abstract: Protein lipidation, a pivotal post-translational modification, dynamically regulates cellular signaling, membrane trafficking, and protein stability, with emerging roles in reproductive physiology. However, the systematic understanding of how distinct lipid modifications orchestrate physiological processes in male and female reproduction remains incomplete. This review systematically elaborates the mechanistic contributions of protein lipidation to gametogenesis, fertilization, and reproductive homeostasis. Finally, we discuss emerging therapeutic strategies targeting lipidation pathways-including inhibitors of palmitoylation (2-BP) and prenylation (lonafarnib)-and highlight their potential for treating infertility and reproductive disorders.
Source: Biomolecules
DOI: 10.3390/biom16030389
Authors: Heran Cao, Xiaohua Liu, Shenghui Zhu, Hua Nie, Shujuan Liu, Jun Fan, Weibing Qin
Institutions: Jinan University, Northwest A&F University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,258
Awards: G2508118322, G6079946770
OpenAlex ID: W7133635835