Nano Hydroxyapatite: Bone Graft Innovation
Year: 2026
Type: article
Abstract: Nanocrystalline hydroxyapatite (n-HA) is the primary inorganic constituent found in hard tissues.. The development of commercial synthetic analogues, known as ‘biomimetic’ materials, has garnered significant attention due to their ability to closely replicate the physicochemical characteristics of biological apatite compounds. With enhanced osseointegrative properties, nano-hydroxyapatite (n-HA) stands out as a promising class of bone graft materials, offering improved compatibility and functionality for regenerative applications. Nano-hydroxyapatite (n-HA) exhibits a strong affinity for bone tissue, where it promotes bone healing by stimulating osteoblast activity and enhancing the expression of local growth factors. Clinical studies using nanocrystalline hydroxyapatite bone grafts in the treatment of human periodontal intrabony defects have demonstrated significant benefits, including reductions in pocket depth and osseous lesion depth, as well as statistically significant gains in clinical attachment levels. n-HA presents multiple benefits for periodontal tissue regeneration, such as low patient morbidity, excellent biocompatibility, and a non-toxic profile. These qualities make it a highly favorable option for promoting effective and safe tissue repair.
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7133785381
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