Modular noncovalent functionalization of electrospun piezoelectric scaffolds with bioactive nanocarriers
Year: 2026
Type: article
Abstract: Electrospun scaffolds offer a promising platform for immune-instructive materials, but stable and modular functionalization with bioactive signals remains a technical challenge. Here, we develop a surface coating strategy for electrospun scaffolds that consist of poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE), a piezoelectric polymer, using electrostatic adsorption of charged nanoparticles. We show that under certain conditions, these piezoelectric scaffolds are suitable substrates for electrostatic self-assembly, and that the density of nanoparticle coatings can be tuned by adjusting buffer pH, ionic strength, and nanoparticle concentration. This approach enables robust and uniform coating with both polymeric nanoparticles and soft nanocarriers such as liposomes, without requiring covalent surface modification of the scaffold. Liposome-coated scaffolds are cytocompatible with adherent epithelial and suspension immune cells and support lipid exchange at the cell-material interface. Using a supramolecular tethering strategy, we use liposome coatings to present interleukin-15 (IL-15) from the scaffold surface and demonstrate localized, sustained cytokine signaling. Together, these findings establish a modular approach for post-fabrication, noncovalent scaffold functionalization with bioactive nanocarriers, offering new opportunities for tissue and immune engineering.
Source: Biomaterials Science
Authors: Sarah Payne Bortel, Sumayia Saif Jaima Chowdhury, Jeremy Cheng, Daniella Uvaldo, Mackenzie Wright, Anna Marie Kylat, Treena Livingston Arinzeh, Santiago Correa
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Funders: National Science Foundation, Simons Foundation, Center for Strategic Scientific Initiatives, National Cancer Institute, National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, Division of Materials Research, Division of Civil, Mechanical and Manufacturing Innovation
OpenAlex ID: W7133889576