Work

Novel drugs targeting genetic variants: current applications and future prospects in heart failure treatment

Year: 2026

Type: article

Abstract: Chronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes. This study analyzes novel drugs targeting genetic mutations that have been launched in recent years, such as sodium-glucose co-transporter 2 inhibitors, angiotensin receptor neprilysin inhibitors, soluble guanylate cyclase, cardiac myosin activators, potassium channel openers, and vasopressin receptor antagonists, compares the drug action mechanisms, key clinical trial data in the research, and the application of real-world research, and discusses the clinical value and existing problems of new drugs.

Source: Frontiers in Molecular Biosciences

DOI: 10.3389/fmolb.2026.1781854

Authors: Xiang Li, Suwen Bai, Yumei Luo

Institutions: Guangdong Medical College, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen

Language: English

Topic: Heart Failure Treatment and Management

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801