Work

Eremophilane sesquiterpenes from Ligularia macrophylla

Year: 2026

Type: article

Abstract: Seven eremophilanes, including three previously undescribed compounds, were extracted and purified from whole plants of Ligularia macrophylla. Their structures, including absolute configurations, were characterized by spectroscopic, quantum chemical NMR, and Single-crystal X-ray methods. The antibacterial activity of these compounds was evaluated against Escherichia coli and Bacillus subtilis. Among them, compound 4 exhibited the most potent antibacterial activity against B. subtilis, with an inhibition zone of 30.58 ± 2.63 mm at 256 μg/mL. All compounds showed no activity against E. coli, as their minimum inhibitory concentration (MIC) exceeded 5 mg/mL.

Source: Fitoterapia

DOI: 10.1016/j.fitote.2026.107166

Authors: Na Gao, Guo-Li Li, Xiang-Tao Zha, Hong-Ying Yang, Yi-lin He, Tong Shen

Institution: Lanzhou Jiaotong University

Language: English

Topic: Sesquiterpenes and Asteraceae Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,950