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P692: Molecular insights into non-JMD FLT3 internal tandem duplications in intron 14

Year: 2026

Type: conference-abstract

Abstract: Sequencing study showed patient 1 carried a 36-bp duplication (NM_004119.2:c.1806_1837+4dup36, p.?) at 21.7% VAF, with co-occurring NPM1 and TET2 mutations, patient 2 had a 63-bp insertion (NM_004119.2:c.1837+1_1837+2ins63, p.?) at 23.3% VAF, along with IDH2, NRAS, and SRSF2 mutations and patient 3 carried a 96-bp insertion (NM_004119.2:c.1837+1_1837+2ins96, p.?) at 63.5% VAF. All FLT3-ITDs included partial duplication of exon 14. The inserts were integrated in-frame within intron 14, immediately downstream of 1–4 intronic nucleotides.

Source: Genetics in Medicine Open

DOI: 10.1016/j.gimo.2026.104182

Authors: Riku Das, Tu Zheng

Institution: Cleveland Clinic

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,200

OpenAlex ID: W7133968207

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