Work

Ubiquitin-conjugating Enzymes in Cancer

Year: 2026

Type: article

Abstract: Ubiquitin-conjugating enzymes (E2s) are emerging as critical regulators of oncogenic signaling networks by modulating protein stability, localization, and interactome dynamics. Distinct E2s orchestrate ubiquitin chain topology to drive cancer hallmarks including proliferation, immune evasion, metastasis, and metabolic reprogramming. Despite their central role in the ubiquitin-proteasome system, E2s remain underexploited as therapeutic targets. This review systematically maps E2-mediated signaling mechanisms across cancer types and proposes translational strategies for E2-targeted intervention.

Source: International Journal of Biological Sciences

DOI: 10.7150/ijbs.130297

Authors: Zhiyang Yao, Ti Peng, Hao Dong, Yong Liao, Kai Miao, Jiang-Jiang Qin, Xiaoqing Guan

Institutions: Chinese Academy of Sciences, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Zhejiang University of Technology, University of Chinese Academy of Sciences, University of Macau, Zhejiang Cancer Hospital

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337

Funders: National Natural Science Foundation of China, Natural Science Foundation of Zhejiang Province

Awards: 白花蛇舌草活性成分车前草苷靶向UCHL3诱导免疫原性铁死亡增强胃癌免疫治疗疗效的机制研究, G6458635722, G7541064859, G8890470309

OpenAlex ID: W7134047734

FWCI: 3.644

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Cited by: 2

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