Work

Is it “Time to Eliminate” Time to Elimination of Symptoms as a Primary Trial End Point for Drugs Targeting Respiratory Viruses?

Year: 2026

Type: article

Abstract: Time to symptom elimination is a statistically inefficient end point for respiratory virus trials that ignores the most clinically relevant time points. Alternatively, clearance slope and area under the curve may efficiently capture improvement early during treatment when symptoms are most severe.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiag148

Authors: Joshua T Schiffer, Shadisadat Esmaeili, Katherine Owens, Michael Boeckh, Alpana Waghmare

Institutions: University of Washington, Fred Hutch Cancer Center, Seattle Children's Research Institute

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases