Work

Differential Cortical and Thalamic Engagement of Cholinergic Interneurons in the Nucleus Accumbens Core

Year: 2026

Type: article

Abstract: Cholinergic interneurons (CINs) in the nucleus accumbens (NAc) play a key role in regulating motivated behaviors. Here we examine the connectivity and functional impact of cortical and thalamic inputs onto CINs in the NAc core. We first use cell-type specific retrograde anatomy to identify the prefrontal cortex and thalamus as putative afferents. We then combine ex vivo slice physiology and optogenetics to characterize the properties of synapses onto CINs. We demonstrate that thalamic inputs strongly facilitate, whereas cortical inputs exhibit marked depression. We also show that a combination of AMPA and NMDA receptors contribute to both cortical and thalamic responses. Lastly, we establish how these inputs and receptors evoke action potentials and influence spontaneous firing. Our findings show how CINs in the NAc core process long-range inputs, highlighting differences from equivalent circuits in other parts of striatum.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.1919-25.2026

Authors: Emily V. Jang, Nigel Dao, Lilly Cole, Adam G. Carter

Institution: New York University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute on Drug Abuse

OpenAlex ID: W7134118730