Work

Micropatterned fibrin scaffolds increase cardiomyocyte alignment and contractility

Year: 2026

Type: preprint

Abstract: Toward the development of a cardiac patch, our laboratory previously developed a cell-populated composite fibrin scaffold and aligned microthreads to recapitulate the mechanical properties of native myocardium. In this study, we explore micropatterning the surfaces of fibrin gels to mimic anisotropic native tissue architecture and promote cellular alignment of human induced pluripotent stem cell cardiomyocytes (hiPS-CM), which is crucial for increasing scaffold contractile properties.

DOI: 10.17605/osf.io/69k3e

Author: Pins, George

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: American Heart Association

Award: Development of Composite-based Cardiac Patch with an Integrated Microvascular Network

OpenAlex ID: W7134129839

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