Work

High-pressure-driven cycloadditions: dearomatization of electron-deficient arenes

Year: 2025

Type: article

Abstract: Dearomative cycloadditions transform planar structures into intricate three-dimensional polycyclic compounds. The scope of these reactions is limited however due to steric or electronic limitations. High-pressure conditions provide an effective way to overcome these challenges, often minimizing the formation of side products and eliminating the need for chemical catalysts. This article showcases recent advances from our group, revealing that high-pressure-induced cycloadditions facilitate the efficient transformation of electron-deficient arenes into complex molecules under conditions that promote sustainable chemistry.

Source: Comptes Rendus Chimie

DOI: 10.5802/crchim.428

Authors: Nathan Noël, Rayhane Hammami, Laëtitia Chausset-Boissarie, Isabelle Chataigner

Institutions: Centre National de la Recherche Scientifique, École Nationale Supérieure d'Ingénieurs de Caen, Université de Rouen Normandie, Institut National des Sciences Appliquées Rouen Normandie, Sorbonne Université, Laboratoire de Chimie Théorique

Language: English

Topic: Organic Chemistry Cycloaddition Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W7134238393

FWCI: 0.29

Cites: 38

Cited by: 1

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