Prognostic Value of NT-proBNP in Patients Undergoing Tricuspid Valve Transcatheter Edge-to-Edge Repair: The EuroTR Registry.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an established marker of myocardial stress, yet its prognostic role in tricuspid valve transcatheter edge-to-edge repair (T-TEER) for tricuspid regurgitation (TR) remains unclear.Objectives To evaluate the prognostic value of baseline NT-proBNP and its early post-procedural trajectory after T-TEER.Methods Patients undergoing T-TEER with available baseline NT-proBNP measurements in the EuroTR Registry were analyzed. NT-proBNP was evaluated continuously and by tertiles, with longitudinal changes assessed when serial measurements were available. Endpoints were the 2-year composite of all-cause mortality or first heart failure hospitalization, changes in NT-proBNP, symptomatic improvement and residual TR.Results 2,282 patients (median age 80 [76-83] years; 54% female; 86% NYHA class III/IV) with baseline NT-proBNP values (T1 ≤1,674 pg/mL, T2 1,674-3,743 pg/mL, and T3 >3,743 pg/mL) were included. Higher tertiles were associated with greater comorbidity burden, more advanced biventricular remodeling, and more severe TR. Baseline NT-proBNP was independently associated with the primary endpoint (adjusted HR: 1.62; 95% CI 1.29-2.04). Residual TR ≤2+ at discharge occurred in 86.3%, 82.9%, and 81.4% across tertiles (P=0.040) and higher NT-proBNP was associated with lower likelihood of symptomatic improvement (adjusted OR per log10 increase: 0.58; 95% CI: 0.44-0.75; P<0.001). Both baseline NT-proBNP and higher-than-expected 30-day levels relative to baseline were independently associated with higher subsequent risk for the primary endpoint.Conclusions Baseline NT-proBNP was independently associated with 2-year mortality or heart failure hospitalization after T-TEER. Early post-procedural NT-proBNP trajectories provided incremental prognostic information and may identify patients at increased risk.
DOI: 10.48620/95988
Authors: von Stein, Jennifer, von Stein, Philipp, Kresoja, Karl-Patrik, Fortmeier, Vera, Pauschinger, Christoph, Rottbauer, Wolfgang, Kassar, Mohammad, Goebel, Bjoern, Denti, Paolo, Achouh, Paul, Rassaf, Tienush, Barreiro-Perez, Manuel, Boekstegers, Peter, Rück, Andreas, Zdanyte, Monika, Adamo, Marianna, Vincent, Flavien, Schlegel, Philipp, Rosch, Sebastian, Wild, Mirjam G, Besler, Christian, Brunner, Stephanie, Toggweiler, Stefan, Grapsa, Julia, Patterson, Tiffany, Thiele, Holger, Kister, Tobias, Tarantini, Giuseppe, Masiero, Giulia, De Carlo, Marco, Voss, Fabian, Sticchi, Alessandro, Polzin, Amin, Rubbio, Antonio P, Bedogni, Francesco, Stolte, Thorald, Nestelberger, Thomas, González, Tomás Benito, Sánchez-Muñóz, Enrique, Swaans, Martin, Timmers, Leo, Konstandin, Mathias H, Van Belle, Eric, Metra, Marco, Geisler, Tobias, Estévez-Loureiro, Rodrigo, Mahabadi, Amir Abbas, Karam, Nicole, Maisano, Francesco, Lauten, Philipp, Praz, Fabien, Kessler, Mirjam, Kalbacher, Daniel, Rudolph, Volker, Lurz, Philipp, Pfister, Roman, Cohen, David J, Granada, Juan F, Hahn, Rebecca T, Hausleiter, Jörg, Stolz, Lukas, Iliadis, Christos
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7134262192
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