Work

Development of a neuroblastoma-on-a-chip bioengineered platform enabling the translational study of emerging nanotherapies

Year: 2026

Type: conference-paper

Abstract: Neuroblastoma (NB) is a developmental cancer with a high level of vascularization. Around 50% of the affected children will develop high-risk NB, and more than half will relapse. The inability to represent complexity and interactions of the human NB hampers clinical translation. In this project, we developed an NB-on-a-chip that can partially recapitulate tumor’s behavior in vitro, allowing testing the efficiency of novel hyperthermia-based nanotherapies. Hyperthermia treatments demonstrated a reduction of cell proliferation specifically in the models treated with nanoparticles. For the biomimetic nanoparticles characterization, two polydisperse populations (exosomes and microvesicles) of EVs/EV-NPs were found, presenting negative ζ- potential. Perfusion system in the NB-on-a-chip allowed the systemic administration of nanotherapies mimicking tumor vasculature overnight.

DOI: 10.31428/10317/13664

Authors: Quiñonero Gema, Gallo Juan, Magalhaes Andreia, Samitier Josep, Villasante Aránzazu

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: Generalitat de Catalunya, Instituto de Salud Carlos III, European Regional Development Fund

Awards: G1041450006, G166663647, G4704457972, G497629119, G7174752950

OpenAlex ID: W7134288018

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