Work

Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome.

Year: 2007

Type: article

Abstract: We describe two patients with a severe Cushing's syndrome due to ectopic production of ACTH. Both patients developed a life-threatening Pneumocystis jiroveci pneumonia (PCP) shortly after treatment of the hypercortisolism was started by means of inhibition of production of glucocorticoids and glucocorticoid receptor blockade. We presume that the restored immune response elicited the clinical symptoms of the opportunistic, previously subclinical Pneumocystis jiroveci infection. The immunocompromised state and the delicate glucocorticoid balance in patients with a severe Cushing's syndrome necessitate a specific diagnostic and therapeutic approach.

Source: PubMed

Authors: J K Oosterhuis, G van den Berg, W E Monteban-Kooistra, J J M Ligtenberg, J E Tulleken, J H J M Meertens, J G Zijlstra

Institutions: University Medical Center Groningen, University of Groningen

Language: English

Topic: Pneumocystis jirovecii pneumonia detection and treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W71343507

FWCI: 1.014

Cites: 16

Cited by: 24

Related to: 10