The CALLY index: an immuno-inflammatory and nutritional index for predicting contrast induced nephropathy in patients with non-ST-elevation myocardial infarction
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background The C-reactive protein–albumin–lymphocyte (CALLY) index integrates inflammation, nutrition, and immunity. Its value for predicting contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is uncertain. We examined whether CALLY predicts CIN in non–ST-elevation myocardial infarction (NSTEMI).Methods A total of 199 consecutive patients with NSTEMI who underwent PCI were retrospectively analyzed. Independent predictors were identified by multivariable logistic regression; discriminative performance was evaluated with receiver-operating characteristic (ROC) analysis.Results CIN occurred in 32 patients (16.1%). Patients with CIN had lower CALLY values [0.49 (0.05–1.71) vs. 1.79 (0.51–4.06); p < 0.001], lower HDL-cholesterol, higher baseline creatinine, and lower estimated glomerular filtration rate. In multivariable models, CALLY independently predicted lower CIN risk (odds ratio [OR] 0.781; 95% confidence interval [CI] 0.625–0.977; p = 0.031) alongside baseline creatinine (OR 6.002; 95% CI 1.196–30.123; p = 0.029) and HDL-cholesterol (OR 0.945; 95% CI 0.900–0.993; p = 0.024). CALLY showed moderate discrimination (AUC 0.697; p < 0.001); the optimal cutoff was 1.1074 (sensitivity 61.1%, specificity 62.5%).Conclusion A lower CALLY index is independently associated with an increased risk of CIN in NSTEMI patients undergoing PCI. The CALLY index may serve as a tool for early risk stratification and targeted preventive strategies in this high-risk population.
Source: Biomarkers in Medicine
Institution: Aksaray University
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7134808772