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Cytotoxic evaluation of 6-metoxy tetrahydro-β-carboline derivatives (6mthβc) in human neuroblastoma (sk-n-sh) cells

Year: 2025

Type: conference-paper

Abstract: Tetrahydro-β-carboline (THβC) alkaloids, a varied group of indole-derived chemicals, demonstrate pharmacological actions including anticancer, antibacterial, antioxidant, and neuroactive effects in nature. In this study, 6-methoxy-tetrahydro-β-carboline (6MTHβC) has been synthesized and evaluated for its toxicity against the human neuroblastoma cell line (SK-N-SH) using the MTT assay. The assay was conducted at a concentration of 50 μM of each compound. The findings showed that four compounds exhibited toxicity toward SK-N-SH cells, while eight compounds demonstrated more than 50% cell viability. This study provides fundamental toxicological insights into these compounds and lays the groundwork for pharmacological and potential new treatment possibilities related to neurodegenerative disease.

Source: UiTM Institutional Repositories (Universiti Teknologi MARA)

Authors: Mohamed, Siti Mazleena, Ezzat, Mohammed Oday, Mordi, Mohd Nizam

Institutions: Universiti Teknologi MARA System, Universiti Teknologi MARA, University of Anbar, Universiti Sains Malaysia

Language: English

Topic: Synthesis and bioactivity of alkaloids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7134872890

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