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Additional file 2 of Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy

Year: 2026

Type: other

Abstract: Supplementary Material 2. Supplementary Fig S2. α-Cre; Ndufs4fl/fl animals show axonal degeneration at 4 months. A) Paraphenylenediamine (PPD) staining to label myelinated axons in optic nerve sections demonstrates axonal loss in α-Cre; Ndufs4fl/fl animals. Note that the degeneration is stronger in the periphery of the optic nerve. B) Quantification of the number of axons in PPD-stained optic nerve sections. Multiple t-tests, **P < 0.01 and ***P < 0.001).

Source: Figshare

DOI: 10.6084/m9.figshare.31641567

Authors: Santamaría-Muñoz, Daniela, Reyes, Raenier V., Krueger, Miranda R., García-Llorca, Andrea, Marsh-Armstrong, Brennan, Duan, Xin, Hu, Yang, Welsbie, Derek S., Marsh-Armstrong, Nicholas, Sanz, Elisenda, Quintana, Albert, Simó, Sergi, La Torre, Anna

Institutions: University of California, Davis, Maine Medical Center, Maine Medical Center, University of California, San Francisco, Stanford University, University of California San Diego, Universitat Autònoma de Barcelona

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7134897015

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