Work

Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs

Year: 2026

Type: article

Abstract: This is a translational research study that demonstrated that with left ventricular pressure overload, such as that which occurs with hypertension, that an exercise program can prevent changes in heart muscle function and structure, which in turn lead to heart failure.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00668.2025

Authors: Stephanie L. Samani, Shayne C. Barlow, Lisa A. Freeburg, Grayson M. Catherwood, Amelia M. Churillo, Traci L. Jones, Jumanah Al-Soudi, Ricky Ruiz, Francesco K. Yigamawano, Tarek Shazly, Michael R. Zile, Francis G. Spinale

Institutions: University of South Carolina, Columbia VA Health Care System, Medical University of South Carolina

Language: English

Topic: Cardiovascular and exercise physiology

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Institute of General Medical Sciences

Awards: G1446469752, G2500050464, G6551011724, G7080609578, The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC), Fibroblast targeting for myocardial repair

OpenAlex ID: W7134919882

FWCI: 9.489

Cites: 49

Cited by: 1

Related to: