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A chance for Rituximab in Primary Biliary Cholangitis–Autoimmune Hepatitis Overlap Syndrome.

Year: 2026

Type: article

Abstract: Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) may coexist as an overlap syndrome, which can be challenging to diagnose and manage. In this case report, we describe a patient with AIH–PBC overlap syndrome refractory to conventional immunosuppressive therapy and with steroid-dependent disease. Rituximab was administered as rescue therapy, achieving biochemical normalization. This case supports the potential role of rituximab as a therapeutic option in patients refractory to standard immunosuppressive treatments.

Source: Revista Andaluza de Patología Digestiva

DOI: 10.37352/2026491.5

Authors: J Pereira Martinez, A Ruiz Sánchez, I Herrería Fernández, JM Sousa Martín

Institution: Hospital Universitario Virgen del Rocío

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7134923322

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