Retrospective study on the effectiveness of clinical pharmacists’ consultation in the management of carbapenem-resistant organisms infections
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: The emergence and global dissemination of carbapenem-resistant organisms (CROs) pose a significant public health threat. Clinical pharmacists play a pivotal role in optimizing antimicrobial therapy through their expertise in pharmacokinetics, pharmacodynamics, and antimicrobial stewardship. Objective: This study aimed to assess the impact of clinical pharmacists' consultations on treatment outcomes in patients with CRO infections. Methods: A retrospective observational study was conducted using data from patients hospitalized at the First Hospital of Jilin University. Patients who received pharmacist consultations were compared with those who did not. The primary outcomes included clinical improvement and mortality rates. Results: A total of 285 patients were included. The acceptance rate (AR) of consultation suggestions by clinicians was 89.82%, and the effective response rate (ERR) was 74.03%. Significant differences were observed between the acceptance and non-acceptance groups regarding effective response and mortality. Patients in the non-acceptance group had a lower effective response rate (20.69% vs. 80.08%) and a higher mortality rate (44.80% vs. 9.76%). Multivariate analysis confirmed that acceptance of pharmacists' recommendations was an independent predictor of effective response (OR = 23.72, 95% CI [7.823-71.917], P < 0.001). Conclusion: Clinical pharmacists' consultations significantly improve treatment outcomes in patients with CRO infections. The acceptance of pharmacists' recommendations is associated with higher effective response rates and lower mortality, underscoring the importance of integrating clinical pharmacists into multidisciplinary teams managing CRO infections.
Source: Frontiers in Pharmacology
Authors: Jie Ma, Xiuyan Li, Xiaoyue Liu, Yueming Zhang, Sixi Zhang
Institutions: Jilin University, First Hospital of Jilin University
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7134926455