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Case Report: Rapid progression of inflammation-driven coronary artery lesions in a normolipidemic patient with ANCA-associated vasculitis complicated by Stanford type A aortic dissection

Year: 2026

Type: article

Abstract: Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune small- to medium-vessel vasculitis. Reports of rapidly progressive left main/left anterior descending (LM/LAD) disease under normolipidemic conditions with parallel coronary-aortic progression are scarce. Case presentation: We report a case of perinuclear antineutrophil cytoplasmic antibody (p-ANCA) and myeloperoxidase (MPO)-positive ANCA-associated vasculitis (AAV) in which, despite persistently normal lipid levels, the coronary arteries developed rapidly progressive stenosis and occlusion within one year. Intravascular ultrasound (IVUS) revealed concentric thickening of the coronary arterial wall characterized predominantly by soft plaques with minimal calcification, which was consistent with an inflammation-driven remodeling phenotype. Because the admission electrocardiogram (ECG) revealed an ST-segment elevation myocardial infarction (STEMI)-equivalent pattern (aVR ST elevation with diffuse ST depression), the patient was treated for acute myocardial infarction, and urgent LM-to-LAD drug-eluting stent (DES) implantation was performed. During a four-month follow-up after discharge, no recurrent angina or ischemic events were reported. Conclusion: In a p-ANCA/MPO-positive AAV patient with sustained normolipidemia, we observed rapidly progressive LM/LAD disease occurring in parallel with aortic involvement, which was consistent with an inflammation-driven coronary phenotype that precipitated acute coronary syndrome. Integrating sequential coronary-aortic imaging with inflammatory biomarker surveillance and individualized immunomodulatory and antithrombotic strategies may enable earlier risk detection and optimize outcomes in patients with AAV.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2026.1736895

Authors: Guangzhen Lu, Xiaoting Wang, Xinye Wang, Hong Zhuang, Gang Zhao

Institutions: Shandong Provincial Hospital, Shandong First Medical University

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801